Autologous serum for ocular surface diseases

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Autologous serum eye drops for ocular surface disorders

Tears have antimicrobial, nourishing, mechanical, and optical properties. They contain components such as growth factors, fibronectin, and vitamins to support proliferation, migration, and differentiation of the corneal and conjunctival epithelium. A lack of these epitheliotrophic factors—for example, in dry eye, can result in severe ocular surface disorders such as persistent epithelial defect...

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[Autologous serum-eye-drops for ocular surface disorders. A literature review and recommendations for their application].

The natural tear film has mechanical, optical, antimicrobial and nutritional properties. Tear film components, such as EGF, fibronectin and vitamin A, play a vital role in the proliferation, migration and differentiation of the corneal and conjunctival epithelium. In ocular surface disease, such as severe dry eye, the epithelia may be depleted of these nutritional factors. Replacing the aqueous...

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Evaluation of the Efficacy of 50% Autologous Serum Eye Drops in Different Ocular Surface Pathologies

PURPOSE This study evaluated the efficacy of 50% autologous serum eye drops in ocular surface diseases not improved by conventional therapy. METHODS We analyzed two groups: (1) acute eye pathologies (e.g., chemical burns) and (2) chronic eye pathologies (e.g., recurrent corneal erosion, neurotropic keratitis, and keratoconjunctivitis sicca). The patients were treated for surface instability a...

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[Keratoprosthesis in cornea and ocular surface diseases].

In 1771, Guillaume Pellier de Quengsy,1 an ophthalmologist, proposed for the first time the possibility of substituting opacifie corneal tissue by “an artificial cornea”. The proposal was for transparent glass plates to substitute the opaque cornea in order to enhance the transparency of optic media. Improvements in topical and systemic immunosuppression and limbus transplant techniques for tre...

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[Use of autologous serum in hypovitaminosis-induced ocular pathology].

CASE REPORT We present two case reports of patients suffering from severe corneal damage resulting in pain and visual impairment, after undergoing Scopinaro's operation. Both patients improved after treatment with topical autologous serum although their nutritional state became worse. DISCUSSION Topical autologous serum provides growth factors and nutrients needed for corneal cell repair, and...

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ژورنال

عنوان ژورنال: Arquivos Brasileiros de Oftalmologia

سال: 2008

ISSN: 0004-2749

DOI: 10.1590/s0004-27492008000700010